Uncle Joe has Down Syndrome and must leave his home at the hospital because it's closing. He goes to live with his sister and her family. His family learns to live with him and to love him.

Marina and Moira are very much alike, and yet very different. They like to play with one another, but often have conflicts. They learn to work through their differences and become the best of friends.

Nathan learns that his new baby sister has Down Syndrome. Nathan wants to help his special sister. He works with his parents to complete Veronica's baby book.

When it is time for Misty to go to sleep, she cannot find her stuffed monkey, Chimpy. Her dad helps his daughter with Down's Syndrome to retrace her day and find her monkey in the process.

A developmentally challenged girl named Cindy finds love and companionship in a puppy she names Smudge. However, the home where Cindy lives does not allow pets, so the puppy is taken away. With the help of her friends at Hospice, a perfect solution is thought of so that Smudge is taken care of and everyone can benefit from his companionship.

Freddie thinks his new neighbor, Sam, is annoying. Freddie does not understand that Sam has Down's Syndrome, and he needs a friend.

Dustin is very excited for the guests that are visiting his school one day. Along with the rest of his students, Dustin goes through his daily school routine awaiting the arrival of Dave and Skippy. When the time finally comes, the reader learns who Dave and Skippy actually are.